ACE inhibitors

All ACE inhibitors except captopril and lisinopril are prodrugs

Enalapril—->Enalaprilat

Enalapril has a half life on 1.3 hours only but enalaprilat has a halflife of 11 hours

Lisinopril is lysine analogue of enalapril with half life of 12 hours.

All ACE inhibitors are cleared as intact compound by kidney except fosinopril and moexipril.

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