Deposition of Amyloid in tissues
Amyloid proteins
AL/Amyloid light chain
Derived from plasma cells and contain immunoglobulin light chains
Associated with primary amyloidosis
Multiple myeloma, Monoclonal B cell proliferation
AA/Amyloid associated protein
Non immunoglobulin protein synthesized by Reticulo endothelial cells of liver
Associated with secondary/reactive systemic amyloidosis
Chronic inflammatory conditions
- TB
- Bronchiectasis
- Osteomyelitis
Connective tissue disorders
- Rheumatoid arthritis
- Ankylosing spondylitis
- Primary biliary cirrhosis
Non immune disorders
- Renal cell Ca
- Hodgkins lymphoma
Less common forms
- Beta 2 microglobulin-Hemodialysis associated amyloid
- Beta 2 amyloid protein(ABeta)-Senile cerebral,Alzheimers
- Transthyretin(ATTR)-Familial amyloidotic neuropathies,sysstemic senile amyloidosis
- Calcitonin associated amyloid(A cal)-Medullary Ca thyroid
- Islet amyloid peptide(AIAPP)-Type II diabetes
- Atrial natriuretic factor associated amyloid(AANF)-Isolated atrial amyloidosis,Prion disease
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