Anti tumour Monoclonal antibodies

Monoclonal antibodies against tumour cells mainly act via antibody dependent cellular cytotoxicity.

They also act via complement mediated lysis and by induction of apoptosis.

Drugs

Rituximab – CD20 – Non Hodgkins Lymphoma

Ibritumomab -CD20 -NHL

Tositumomab- CD20- NHL

Ofatumumab -CD20 -NHL,CLL

Alemtuzumab- CD52- CLL

Gemtuzumab – CD33- AML

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