Category Archives: Pathology

Wilms tumour and associated syndromes

Wilms tumour Also known as nephroblastoma. Wilms tumour is the most common primary renal tumour in children. Usually wilms tumour is a solitary,well circumscribed lesion,but 10% is bilateral or multicentric. Triphasic combination of epithelial,stromal and blastemal elements. 5% show anaplasia …

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Metastatic calification Vs Dystrophic calcification

Metastatic Calcification Due to deranged Calcium metabolism Increased calcium concentration in serum Mitochondria are the organelle first involved Alkaline PH favours precipitation of calcium salts Sites involved in metastatic calcification are: Alveolar wall of lungs(Most common site) Basement membrane and …

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Adenoid cystic carcinoma

Adenoid cystic carcinoma is also called cylindroma . Constitute 10% of all salivary neoplasm 65% of minor salivary gland tumours are malignant, of them 40% are adenoid cystic carcinomas. Most common malignant tumour of minor salivary glands Seen equally in …

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Nuclear and cytoplasmic inclusion bodies.

Intracytoplasmic Inclusion bodies Negri bodies – Rabies Guarneiri bodies – Vaccinia Bollinger bodies – Fowlpox Molluscum bodies -Molluscum Contagiosum Poschen bodies- Small Pox Nuclear inclusion bodies Cowdry type A – Herpes virus, yellow fever virus. Cowdry type B- Adenovirus.

Microscopic appearances of RBC’s in specific diseases

Examination of peripheral smear often provides valuable clues for diagnosis of specific disease conditions. Appearances of RBC’s on peripheral smear can be useful in diagnosing conditions listed below Spherocytes Autoimmuune hemolysis Hereditary spherocytosis Post splenectomy DIC Clostridium Welchii septicemia Burns …

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HLA’s associated with specific diseases

  HLA types associated with various diseases is a hot favorite question of many PG exams. So pooling all these HLA types and the diseases associated with them seemed to be a good idea. Given below is a list of …

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Multiple myeloma

Durie and Salmon myeloma diagnostic criteria Major criteria Plasmacytoma on tissue biopsy Bonemarrow plasmacytosis with 30% plasma cells Monoclonal globulin spike(M spike) on Serum protein electrophoresis(SPEP):IgG>3.5g%,IgA>2g%,light chain excretion on UPEP>=1g/24hr in absence of amyloidosis Minor criteria Bonemarrow plasmacytosis with 10-30% …

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