Pharmacology | Master Of Medicine

Category Archives: Pharmacology

Mechanism of action of fluoroquinolones

Fluoroquinolones act by inhibiting nucleic acid synthesis of bacteria.These drugs inhibits the action of DNA gyrase(Topoisomerase II) and Topoisomerase IV which are essential for removing supercoils formed during  DNA replication,when replication fork proceeds downstream

Anti tumour Monoclonal antibodies

Monoclonal antibodies against tumour cells mainly act via antibody dependent cellular cytotoxicity.

They also act via complement mediated lysis and by induction of apoptosis.


Rituximab – CD20 – Non Hodgkins Lymphoma

Ibritumomab -CD20 -NHL

Tositumomab- CD20- NHL

Ofatumumab -CD20 -NHL,CLL

Alemtuzumab- CD52- CLL

Gemtuzumab – CD33- AML

Anti arrythmic drugs classification

Anti arrhythmic drugs are classified into four main classes.

Class I – Sodium channel blockers(act on Phase 0)

Class II – Beta blockers(act on phase 4)

Class III- Potassium channel blockers(act on phase 3)

Class IV – Calcium channel blockers(act on phase 2)

Class I- Na+ channel blockers

Class IA – Quinidine, Procainamide, Disopyramide

Class IB -Lidocaine,Phenytoin,Mexiletine,Tocainide

Class IC -Flecainide,Encainide,Propafenone,Morocizine

Class II -Beta blockers


Class III- K+ Blockers


Class IV – Ca2+ blockers


Adverse effects of Amioderone

  1. Hyper/Hypothyroidism
  2. Peripheral neuropathy
  3. Myocardial depression
  4. Lung fibrosis
  5. Liver toxicity
  6. Corneal microdeposits
  7. Photosensitivity

Selective Beta1 blockers

Mnemonic: Beta Blockers Acting Exclusively At Myo Cardium

  1. Beta- Betaxolol
  2. Blockers-Bisoprolol
  3. Acting-Atenolol
  4. Exclusively- Esmolol
  5. At- Acebutolol
  6. Myo- Metoprolol
  7. Cardium- Celiprolol

Anti tubercular drugs


  1. Rifampicin
  2. INH
  3. Streptomycin
  4. Pyrazinamide


  1. Ethambutol
  2. Thicetazone
  3. PAS
  4. Cycloserine

Drugs causing Pancreatitis

Drugs causing pancreatitis are:


1 -ACE inhibitors
2 -Didanosine
3 -Trimethoprim
4 -Tetracycline
5 -Pentamidine

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