Fluoroquinolones act by inhibiting nucleic acid synthesis of bacteria.These drugs inhibits the action of DNA gyrase(Topoisomerase II) and Topoisomerase IV which are essential for removing supercoils formed during DNA replication,when replication fork proceeds downstream
Category Archives: Pharmacology
Monoclonal antibodies against tumour cells mainly act via antibody dependent cellular cytotoxicity.
They also act via complement mediated lysis and by induction of apoptosis.
Rituximab – CD20 – Non Hodgkins Lymphoma
Ibritumomab -CD20 -NHL
Tositumomab- CD20- NHL
Ofatumumab -CD20 -NHL,CLL
Alemtuzumab- CD52- CLL
Gemtuzumab – CD33- AML
Anti arrhythmic drugs are classified into four main classes.
Class I – Sodium channel blockers(act on Phase 0)
Class II – Beta blockers(act on phase 4)
Class III- Potassium channel blockers(act on phase 3)
Class IV – Calcium channel blockers(act on phase 2)
Class I- Na+ channel blockers
Class IA – Quinidine, Procainamide, Disopyramide
Class IB -Lidocaine,Phenytoin,Mexiletine,Tocainide
Class IC -Flecainide,Encainide,Propafenone,Morocizine
Class II -Beta blockers
Class III- K+ Blockers
Class IV – Ca2+ blockers