Drug induced lupus, drugs causing it.

Features of drug induced lupus are:

  • ANA positive,Anti Histone antibody positive.
  • Caucasians are more affected.
  • Less female predilection compared to SLE.
  • Rarely involves kidney or brain.
  • Rarely associated with anti ds DNA positivity.
  • ANA will be positive even before the appearance of symptoms.

Drugs causing drug induced lupus.

  • Anti arrhythmic drugsĀ  – Procainamide,disopyramide,propafenone.
  • Anti hypertensives — Hydralazine
  • ACE inhibitors and Beta blockers
  • Anti thyroid – Propylthiouracil
  • Antipsychotics – Chlorpromazine, Lithium
  • Anticonvulsants – Carbamazepine,Phenytoin
  • Antibiotics – Isoniazid, Minocycline, Macrodantin
  • Antirheumatic – Sulfasalazine
  • Diuretic – Hydrochlorothiazide
  • Anti hyperlipidemic – Lovastatin, Simvastatin
  • Interferons and TNF alfa inhibitors


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