Drug induced lupus, drugs causing it.
Posted by admin
on May 25, 2011
Features of drug induced lupus are:
- ANA positive,Anti Histone antibody positive.
- Caucasians are more affected.
- Less female predilection compared to SLE.
- Rarely involves kidney or brain.
- Rarely associated with anti ds DNA positivity.
- ANA will be positive even before the appearance of symptoms.
Drugs causing drug induced lupus.
- Anti arrhythmic drugs – Procainamide,disopyramide,propafenone.
- Anti hypertensives — Hydralazine
- ACE inhibitors and Beta blockers
- Anti thyroid – Propylthiouracil
- Antipsychotics – Chlorpromazine, Lithium
- Anticonvulsants – Carbamazepine,Phenytoin
- Antibiotics – Isoniazid, Minocycline, Macrodantin
- Antirheumatic – Sulfasalazine
- Diuretic – Hydrochlorothiazide
- Anti hyperlipidemic – Lovastatin, Simvastatin
- Interferons and TNF alfa inhibitors
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