Master Of Medicine

Features of drug induced lupus are:

• ANA positive,Anti Histone antibody positive.
• Caucasians are more affected.
• Less female predilection compared to SLE.
• Rarely involves kidney or brain.
• Rarely associated with anti ds DNA positivity.
• ANA will be positive even before the appearance of symptoms.

Drugs causing drug induced lupus.

• Anti arrhythmic drugs  – Procainamide,disopyramide,propafenone.
• Anti hypertensives — Hydralazine
• ACE inhibitors and Beta blockers
• Anti thyroid – Propylthiouracil
• Antipsychotics – Chlorpromazine, Lithium
• Anticonvulsants – Carbamazepine,Phenytoin
• Antibiotics – Isoniazid, Minocycline, Macrodantin
• Antirheumatic – Sulfasalazine
• Diuretic – Hydrochlorothiazide
• Anti hyperlipidemic – Lovastatin, Simvastatin
• Interferons and TNF alfa inhibitors