Drugs and side effects

Indinavir- Renal complications because it is mainly excreted via kidney,nephrolithiasis

Avascular necrosis of femoral head is common with protease inhibitors also with steroids.

Drugs causing constipation
  1. Aluminium hydroxide
  2. Barium sulphate
  3. CaCo3
  4. FeSO4
  5. Ganglionic blockers
  6. Ion exchange resins
  7. Opiates
  8. Phenothiazines
  9. Tricyclic antidepressants
  10. Verapamil

Etidronate a first generation bisphosphonate inhibits minerallisation of bone along with resorption by osteoclasts, so its side effect is osteomalacia

Diazepam generates active metabolites,has slow elimination and tend to accumulate with steady use so not preferred in elderly

Valproate may precipitate phenobarbitone and phenytoin toxicity.It may precipitate absence status when used with clonazepam.

Drugs causing megaloblasic anemia(due to folate deficiency)

Interference with folic acid absorption

  • Phenytoin
  • Phenobarbitone
  • Primidone
  • Sulfasalazine
  • Cotrimoxazole

Inhibition of dihydrofolate reductase

  • Methotrexate
  • Pyrimethamine
  • Triamterene
  • pentamidine
  • trimethoprim

Fluoxetine therapy-loose stools

Clozapine

Atypical antipsychotic with minimal extapyramidal side effects, weak D2 blocking action no hyper prolactinemia.

  • Agranulocytosis
  • Seizures
  • Sedation
  • Urinary incontinence
  • weight gain
  • Tachycardia,unstable BP

Haloperidol

Antipsychotic with extrapyramidal side effects,high potency low sedation,low anticholinergic effects.

  • Akathesia
  • Acute dystonia
  • parkinsonism

Depression: 5 drugs causing it

Mnemonic:PROMS

  1. Propranolol
  2. Reserpine
  3. Oral contraceptives
  4. Methyl dopa
  5. Steroids

Beta-blockers side effects

  1. Bradycardia
  2. Bronchoconstriction
  3. Claudication
  4. Hyperlipidemia
  5. Vivid dreams & nightmares
  6. -ve Inotropic action
  7. Reduced sensitivity to hypoglycaemia

Amiodarone: action, side effects

6 P’s:

  1. Prolongs action potential duration
  2. Photosensitivity
  3. Pigmentation of skin
  4. Peripheral neuropathy
  5. Pulmonary alveolitis and fibrosis
  6. Peripheral conversion of T4 to T3 is inhibited -> hypothyroidism

Phenyl proponolamine- Used as an appetite suppressant aand decongestion therapies.

Adverse effect is Hemorrhagic stroke

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