Fat soluble Vitamins

Vit A,D,E and K are fat soluble vitamins.

Absorbed mainly from Ileum and dependant on pancreatic function.

Deficiency of fat soluble vitamins occur in obstructive jaundice,because of the inability to form micelles, which aid in the absorption of fat.

Vitamin A -Retinol

Xeropthalmia and night blindness.

Vitamin D

D2-Ergocalciferol

D3-Cholecalciferol,formed in sun exposed skin

Def:Rickets in children,osteomalacia in adults.

1,25 hydroxy cholecalciferol-Calcitriol,active form

Vit E-Antioxidant, Deficiency:Increased fragility of erythrocytes.

Vitamin K

  • Green vegetables and diary products.
  • Synthesized in intestinal flora.
  • Vit K dependant Clotting factors:II,VII,IX,X,Protein C,Protien S.
  • Cause neonatal hemorrhage with prolonged PT,aPTT ,normal Bleeding time.
  • Catalyses gamma carboxylation of glutamyl residues of clotting factors.
  • Warfarin is Vit K antagonist
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