HLA’s associated with specific diseases


HLA types associated with various diseases is a hot favorite question of many PG exams. So pooling all these HLA types and the diseases associated with them seemed to be a good idea. Given below is a list of most frequently asked HLA types.

Diseases and associated HLA

  • Multiple sclerosis- HLA DR2
    Narcolepsy- HLA DR2
    Goodpasture’s syndrome- HLA DR2
    Sjogrens- HLA DR3
    Dermatitis herpetiformis- HLA DR3
    Celiac disease- HLA DR3
    Rheumatoid arthritis- HLA DR4
    Behcets disease – HLA B5
    Congenital adrenal hyperplasia- HLA B47
    SLE- HLA DR2,DR3
    Type 1 Diabetes – HLA DR2,DR3,DR4
    Hyperthyroidism – HLA B8,DR3
    Myasthenia gravis- HLA B8,DR3
    Tuberculoid leprosy- HLA B8,DR3
    VKH syndrome- HLA DW 15,DR4

Conditions associated with HLA B27

  1. Ankylosing spondylitis
  2. Psoriatic arthritis
  3. Reiters syndrome
  4. Reactive arthritis(Yersinia, salmonella,gonococci)
  5. JRA(pauci articular)

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