Malignant Hyperthermia.

  • Life threatening event triggered by administration of anaesthetics and NM blocking agents.
  • Triggered by uncontrolled release of Ca2+ from sarcoplasmic reticulum.
  • Association seen with mutation of gene Ry-R1 encoding for Skeletal muscle Ryanodine receptors
  • Severe hyperthermia,Contracture and rigidity,Metabolic acidosis,Tachycardia are features.
  • Drugs which trigger-Halothane,Sevoflurane,Isoflurane,Succinylcholine
  • Treated by cessation of anaesthetic,IV administration of Dantrolene along with procainamide because of possbility of Ventricular fibrillation.

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