Metastatic Calcification
- Due to deranged Calcium metabolism
- Increased calcium concentration in serum
- Mitochondria are the organelle first involved
- Alkaline PH favours precipitation of calcium salts
Sites involved in metastatic calcification are:
- Alveolar wall of lungs(Most common site)
- Basement membrane and tubular lamina of kidneys
- Interstitial tissue of gastric mucosa
- Systemic arteries
- Pulmonary veins
- Cornea and conjunctiva
- Synovium of joint
- Tendons
Dystrophic calcification
- Macroscopic deposition of Calcium salts in injured tissues
- Extracellular deposition of calcium
- Denatured proteins and dead tissue bind Phophate irreversibly
- Phosphate reacts with calcium and gets precipitated as Calcium Phosphate
Sites Involved
- Tubercular lymphnodes
- Mitral /Aortic valves in Rheumatic fever
- Atherosclerosis of arteries
- Breast tissue

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