Microscopic appearances of RBC’s in specific diseases

Examination of peripheral smear often provides valuable clues for diagnosis of specific disease conditions. Appearances of RBC’s on peripheral smear can be useful in diagnosing conditions listed below


  1. Autoimmuune hemolysis
  2. Hereditary spherocytosis
  3. Post splenectomy
  4. DIC
  5. Clostridium Welchii septicemia
  6. Burns

Target cells

  1. Liver disease
  2. Post splenectomy
  3. Thalassemia
  4. Hb C disease

Howell Jolly bodies

  1. Megaloblastic anemia
  2. Post splenectomy

Basophilic stippling

  1. Lead poisoning
  2. 5′ nucleotidase
  3. Thalassemia
  4. Myelodysplasia
  5. Aplastic anemia


  1. Chronic liver disease

Burr cells

  1. Uremia


  1. Alcoholism

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