Multiple Endocrine neoplasia

Autosomal dominant syndromes.

Two types MEN-I and MEN-II

MEN-I(Wermer Syndrome)

MEN-1 gen

  • Pituitary adenoma
  • Pancreatic tumours
  • Parathyroid hyperplasia


Wemer morrison’s syndrome/watery diarrhoea syndrome:Pancreatic diarrhoea


RET gene

MEN-II A(Sipple’s syndrome)

Associated with


  • Medullary thyroid carcinoma(100%)
  • Pheochromocytoma
  • Marfanoid habitus
  • Mucosal neuromas(>95%)

IMPORTANT:Both MEN-I and MEN-IIA have parathyroid hyperplasia as a common point.

MENIIA and MENIIB have Medullary carcinoma and pheochromocytoma as common point.

Wermer described MEN as having autosomal dominant inheritence pattern.

Sipple described a combination of a pheochromocytoma, medullary thyroid carcinoma and parathyroid adenoma.

In 1974 Sizemore et al showed that the MEN 2 category included two groups of patients with MTC and pheochromocytoma: one with parathyroid disease and a normal appearance (MEN 2A) and the other without parathyroid disease but with mucosal neuromas and mesodermal abnormalities (MEN 2B).

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