Durie and Salmon myeloma diagnostic criteria
Major criteria
- Plasmacytoma on tissue biopsy
- Bonemarrow plasmacytosis with 30% plasma cells
- Monoclonal globulin spike(M spike) on Serum protein electrophoresis(SPEP):IgG>3.5g%,IgA>2g%,light chain excretion on UPEP>=1g/24hr in absence of amyloidosis
Minor criteria
- Bonemarrow plasmacytosis with 10-30% plasma cells
- Monoclonal globulin spike present, but lower than inĀ major criteria
- Lytic bone lesions
- IgM>50mg/dl,IgA>100mg/dl or IgG>600mg/dl
Diagnosis of MM requires 1 major+1 minor or 3 minor that must include both 1st and 2nd minor criteria
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