Oncogenes,proto oncogenes and tumour supressor genes

Oncogenes

Growth factors

Platelet derived growth factor(PsDGF)- sis

Fibroblast growth factor-hst-1,int-2

Growth factor receptors

  1. erb-EGFR(Epidermal Growth Factor Receptor)
  2. fms-CSF-1 receptor
  3. ret-receptor for neurotrophic factor
  4. kit-Receptor for stem cell factor
  5. ros-insulin receptor
  6. erb A- Related to thyroid hormone receptor

Proteins in signal transduction

Protein tyrosine kinases

  1. src
  2. yes
  3. fps
  4. abl
  5. met

Proteins-serine threonine kinases

  1. ras
  2. Phosholipase C related
  3. crk

Nuclear regulatory protein

  1. myc
  2. jun
  3. fos
  4. ski
  5. rel

Cell cycle control

  1. bcl-1/cyclin
  2. mdm-2(p53 antagonist)
  3. CDK4-Cyclin dependant kinases

Proto Oncogenes

  1. ERB-B1- Over expression-Squamous cell Ca lung,Glioma
  2. ERB-B2-Amplification-Breast and Ovarian ca
  3. E-MYC-Translocation-Burkitt Lymphoma
  4. N-MYC-Amplification-Neuroblastomas,Small cell Ca Lung
  5. L-MYC Amplification-Small cell Ca Lung
  6. K-RAS-Point mutation-Colon,Lung,Pancreas
  7. H-RAS-Point Mutation-Bladder and Kidney
  8. N-RAS-Point mutation-Melanomas,Hematologic malignancy

Tumour suppressor genes

  1. TGF beta – Ca stomach
  2. E cadherin-Ca colon
  3. NF1-Neuroblastoma
  4. NF2-Schwannoma,meningioma
  5. APC/beta catenin- Ca stomach,colon,pancreas,melanoma.
  6. PTEN- Endometrial and prostrate ca
  7. SMAD 2 and SMAD 4-Colon,pancreas
  8. RB-Retinoblastoma,Osteosarcoma,Ca breast,colon and lung
  9. P53-most human cancers
  10. WT1-wilms tumour
  11. P16-Pancreatic,breast,esophageal ca
  12. BRCA1 and 2-Breast
  13. KLF6- prostrate

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