Rate Limiting steps in biochemical reactions.

Rate limiting steps in various biochemical reactions taking place inside cells is of vital importance while formulating drugs to fight specific diseases affecting these reactions. So these rate limiting steps are frequently asked in various entrance exams.
Glycolysis – Phosphofructokinase
Glycogen synthesis – Glycogen synthetase
Glycogenolysis – Glycogen Phosphorylase
Gluconeogenesis – Phosphoenolepyruvate; Fructose 1,6 biphosphatase
TCA cycle– Isocitrate dehydrogenase
Cholesterol synthesis– HMG CoA Reductase
Bile acid synthesis – 7 alpha hydroxylase
Fatty acid synthesis – acetyl CoA carboxylase

Ketone body synthesis -HMG CoA synthetase
Uric acid synthesis – Xanthine Oxidase
Norepinephrine(catecholamine) synthesis– Tyrosine hydroxylase
Tyrosine———–>DOPA(Tyrosine hydroxylase)
Acetylcholine synthesis– Uptake of choline
Urea synthesis – Carbamoyl transferase


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