Rosettes

Retinoblastoma-Flexner wintersteiner rosette-True rosette

Mnemonic:RFT

Neuroblastoma-Homer wrights rosette-Pseudorosette

Both these are found in both the above diseases.

Ependymoma-Perivascular pseudorosette

Fluerette-Photoreceptor, specific sign of Retinoblastoma.

In detail

Flexner wintersteiner rosette

A halo of cells surrounding an empty central hub, cytoplasmic projections from surrounding cells project into the lumen

Characteristic of Retinoblastoma

May also be seen in
  1. Medulloblastoma
  2. Pineoblastoma

Homer wright rosette

Central hub with meshwork of fibres(neutrophil rich)

Characteristic of

  1. Neuroblastoma
  2. Medulloblastoma

Also seen in

  1. Primitive Neuroectodermal tumours(PNET)
  2. Pineoblastomas
  3. Retinoblastomas

True ependymal rosette

Empty lumen

Characteristic of ependymoma

Perivascular pseudorosette

No tumour, surrounds a blood vessel

  1. Ependymoma
  2. medulloblastoma
  3. PNET
  4. Central neurosytoma
  5. Glioblastoma
  6. Retinoblastoma
  7. Monomorphous pilomyxoid astrocytomas

Pineocytomatous rosette-Pineocytoma

Neurocytic rosette- Central neurocytoma

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