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Troponin
Troponin is a complex of three regulatory proteins.
Troponin T-Attaches troponin complex to Tropomyosin
Troponin I-Binds troponin complex to actin
Troponin C-Calcium binding troponin
Tropomyosin
Covers the sites where myosin heads bind actin.
Troponin-Tropomyosin complex inhibits the interaction between actin and myosin in a resting muscle.
How does muscle contract?
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Calcium is released from SR in response to action potential and it binds to troponin C and causes conformational change in Troponin-Tropomyosin -Actin unit, myosin binding sites become uncovered leading to muscle contraction.
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